SUNRESIN Seplife® products for Solid Phase Peptide Synthesis (SPPS) from Sunresin are suitable from research to large-scale manufacturing of peptides. They are engineered for high productivity thanks to their high loading, controlled particle size and excellent batch to batch reproducibility. Sunresin’s production capabilities enable the manufacturing of SPPS resins at scales of up to 150 m³. These resins are widely used in the production of key APIs, including semaglutide. Our focus on quality and cost-effectiveness ensures reliable, consistent, and scalable results. In the article “4-Methylbenzhydryl Bromine Resin: Bridging the Gap between 2-Chlorotrityl Chloride and Wang-Type Resins for the Solid-Phase Synthesis of C-Terminal Acid Peptides,” published as a result of the collaboration between Prof. Fernando Albericio and Sunresin team, it is presented a novel approach to peptide synthesis that addresses the longstanding challenges associated with the synthesis of C-terminal acid peptides. Peptides have gained substantial importance in the pharmaceutical, cosmetic, and food industries, recognized as vital biomolecules. Current methods for preparing peptides largely rely on solid-phase peptide synthesis (SPPS), a technique first developed by Nobel Laureate R. Bruce Merrifield in the 1960s. This method utilizes a solid polymeric support to create an efficient pathway for synthesizing peptides by anchoring the first amino acid. C-terminal amide peptides are significantly easier to synthesize compared to their acid counterparts. The main reason for this lies in the inherent stability and formation tendencies of covalent bonds; esters in acid peptides are more labile than amides. The key resins employed in acid peptide synthesis—Wang resin and 2-chlorotrityl chloride (CTC) resin—represent distinct methodologies, each with associated advantages and drawbacks. Wang resin facilitates the synthesis of unprotected peptides and is adaptable, but it can lead to undesirable side reactions such as diketopiperazine (DKP) formation or the potential for amino acid racemization. CTC resin, on the other hand, can accommodate protected peptides but is prone to hydrolysis and thermal instability, especially with longer peptide chains and certain coupling conditions. TWENTYFOURSEVENBIOPHARMA Issue 3 / October 2025 54
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