Purilogics, a Donaldson Life Sciences business specializing in biopharmaceutical membrane chromatography development, today announced the availability of its first manufacturing-grade product within its Purexa™ portfolio—Purexa NAEX (Novel Anion Exchange) Prep membrane technology—to support customers’ GMP processes.
The Purexa NAEX Prep is the first Purilogics product to become available in manufacturing grade. Specifically designed for the purification of supercoiled plasmid DNA (pDNA), the ready-to-use consumable offers easy setup and breakdown and is compatible with most chromatography systems. Manufacturing of the Purexa NAEX membrane technology takes places in an ISO 9001, Class 7 cleanroom certified facility with a quality system and process located in Bloomington, Minnesota, while R&D activities take place at the company’s state-of-the-art innovation center in Greenville, South Carolina.
“We selected the Purexa NAEX membrane chromatography products for our initial expansion into manufacturing-grade offerings due to their broad applicability,” said Jin Zhou, Director of Purilogics. “These products enhance downstream productivity in three key ways: (1) with high dynamic binding capacity, (2) fast cycle times and (3) in an efficient and scalable format. This allows users to process their product more quickly versus traditional chromatography columns, helping reduce process costs as well.”
Additional research-grade and manufacturing-grade products within the Purexa membrane chromatography portfolio will be released throughout 2025 and 2026. The Purexa product portfolio also includes Purexa MCP membrane chromatography products for the polishing of supercoiled pDNA, Purexa OdT membrane chromatography products for mRNA purification, and Purexa PrA membrane chromatography products for capture step antibody purification. Each of the Purexa technologies will be available in a comprehensive range of membrane products including lab-scale “Plate” and “Prep” products, development-scale “Pilot” and large-scale manufacturing “Process” products.
